Dual Benefit Formulation Direct Compression and Solubility Enhancement by Spherical Agglomeration Technique

Abstract

The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Zaltoprofen, a novel NSAID drug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Zaltoprofen spherical agglomerates prepared with sodium alginate, which is hydrophilic polymer by using simple spherical agglomeration technique for enhancing micromeritic properties. The prepared zaltoprofen spherical agglomerates were examined in terms of flow properties, particle size analysis, compression and dissolution behaviour. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by x-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning colorimetry (DSC). The prepared agglomerates were improved the micromeritic properties, packability, wettability, solubility and compaction behaviour in comparison to pure Zaltoprofen drug.