Kinetic analysis of drug release from Nateglinide-loaded ethyl cellulose nanoparticles for oral delivery

Abstract

With the objective to achieve sustained drug release, especially for the oral delivery and thereby to reduce the side effects of administration of conventional dosage form, Nateglinide (NTG)-loaded Ethyl cellulose (EC) nanoparticles have been formulated. These polymeric nanoparticles have been developed by solvent evaporation method and were subjected to in-vitro drug release analysis up to 12 hrs. The formulation demonstrated favourable in-vitro sustained release characteristics. Experimental in-vitro release data were substituted with available mathematical models to establish the mechanism of release of nateglinide and was found to follow Korsmeyer-Peppas release mechanism of diffusion from the polymeric matrix.