Oral Disintegrating Tablet: A Review

Abstract

Comfort of drug administration and patient compliance are important considerations in dosage form design. Strong, adaptable tablets with exceptional flavor masking and controlled release can be produced using new and emerging technology. Solid dose forms known as oral disintegrating tablets (ODTs) dissolve in the mouth in less than 60 seconds, allowing for waterless swallowing. Rapid pill disintegration results in rapid dissolving and, thus, a rapid start of action. Pediatrics, the elderly, psychotic, dysphagic, bedridden, comatose, young patients with underdeveloped neurological and muscular systems, patients with hand tremors, and patients who travel frequently are among the particular populations for which ODTs are an appropriate dosage form. It offers reduced packing size, precise dosing, superior stability, and convenience of manufacture. Since water is not needed during transportation, self-administration is feasible. ODTs are a cost-effective way to distribute medications. When a medicine is absorbed from the buccal cavity, ODTs are a crucial drug delivery method. For the creation of ODTs, a variety of scientific methods have been used, including as molding, direct compression, spray drying, sublimation, and freeze drying. ODTs are becoming more readily accessible as over-the-counter medications for the treatment of a wide range of illnesses. Reviewing ODTs' benefits, drawbacks, formulation difficulties, manufacturing processes, patented technologies, commercial formulations, and evaluation testing is the goal of this article.