Formulation Development And In Vitro Evaluation Of Oral Dissolving Films Of Palonosetron

Abstract

Palonosetron is an5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be more effective than granisetron. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the  problem  of  swallowing  and  using  water.  The  film  were  prepared  by  using  polymers  such  as Polyvinyl alcohol, Maltodextrin and Propylene glycolby a solvent casting method.  They  were  evaluated  for  physical  characteristics  such  as  Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and Invitro Dissolution Studies give satisfactory results. The in vitro dissolution time of the optimized  batch  F4  was  found  to  be  98.97%.  The optimized  batchin vitro disintegration time was  found  to  14 sec.