Formulation And In Vitro Evaluation Of Mesalazine Sustained Release Matrix Tablets

Abstract

The aim of the present study was to develop sustained release formulation of Mesalazine to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 200 M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Where as from the dissolution studies it was evident that the formulation (F9) showed better and desired drug release pattern i.e., 99.9% in 12 hours. It contains the HPMC-K 200 M 1:1as sustained release material. It followed Zero order release kinetics mechanism.