DESIGN AND EVALUATION OF CARVEDILOL TRANSDERMAL PATCHES BY USING SOLVENT EVAPORATION TECHNIQUES

Abstract

Transdermal patches of carvedilol with an Ethylcellulose, HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapour transmission through the patches followed zero-order kinetics. In vitro permeation studies were performed using a K-C diffusion cell across hairless guinea pig skin and followed the super case II transport mechanism. The effects of non-ionic surfactants Tween 80 on drug permeation were studied. The non- -ionic surfactants in the patches increased the permeation rate, Tween80 exhibiting better enhancement. The patches were seemingly free of potentially hazardous skin irritation.