In Vivo Anti Diabetic Activity of Helicteres Isora on Streptozotocin-Induced Diabetic in Rats

Abstract

Solanum pubescens Willd, belongs to the family Solanaceae, have pharmacological actions like hepatoprotective, gastroprotective, anti-inflammatory, antimicrobial ,antihelmethic .

Objetive: To investigate antioxidant activity of methanolic leaf extract of Solanum pubescens Willd., on alloxan induced diabetic rats.

Methods: Alloxan is administered as an inducer for diabetes. Thirty Wistar albino rats were randomly divided into five groups. Either sex of Wister strains of albino rats were divided in to 5 groups were Group 1 served as normal control, Group 2 served as alloxan control, Group 3 were administered with standard drug (Glibenclamide), Group 4 and Group 5 were administered to different doses of methanolic extract of Solanum pubescens Willd., (i.e. 200 and 300 mg/kg/Kg body weight).The anti-diabetic activity was determined by glucometer in both normal and alloxan-induced diabetic rats. The methanolic extract of Solanum Pubescens showed significant reduction in blood glucose levels due to the presence of phytochemicals such as alkaloids in extracts.

Results: Altered levels of the FBGL and OGTT in alloxan induced rats were brought back to normal on treatment with methanolic extract of Solanum pubescens Willd., Thus the positive results suggest that solanum Pubescens extract should be further studied to determine the bioactive chemical compounds as well as to understand the possible mechanism of action and evaluate their toxicity looking towards pharmaceutical actions.

Conclusion: It was concluded from the result that the methanolic extract of Solanum pubescens Willd., showed significant antidiabetic activity  in a dose dependent manner.