ESTIMATION OF MONTELUKAST SODIUM AND FEXOFENADINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY Q-ABSORBANCE METHOD

Authors

  • Ravisankar M Department of Pharmaceutical Analysis, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tamil Nadu, India - 637205.
  • Subasini U ASIA Metropolitan University, Medical campus, Bandar Seri Alalm, Johor Bahru 81750, Malaysia.
  • Ananda Thangadurai S Analysis, Swamy Vivekanandha 1Department of Pharmaceutical College of Pharmacy, Elayampalayam, Tamil Nadu, India - 637205.
  • Jothimanivannan C Analysis, Swamy Vivekanandha 1Department of Pharmaceutical College of Pharmacy, Elayampalayam, Tamil Nadu, India - 637205.
  • Sundaraganapathy R Analysis, Swamy Vivekanandha 1Department of Pharmaceutical College of Pharmacy, Elayampalayam, Tamil Nadu, India - 637205.
  • Prudhvi T Analysis, Swamy Vivekanandha 1Department of Pharmaceutical College of Pharmacy, Elayampalayam, Tamil Nadu, India - 637205.

Keywords:

Fexofenadine hydrochloride, Montelukast sodium, Q-absorbance method.

Abstract

A simple precise, accurate, cost effective method has been developed for the estimation of Montelukast sodium and Fexofenadine hydrochloride in combined tablet dosage form by Q-absorbance method. The isobestic point was found at 226 nm. The developed method showed linearity in the range of 5-25 µg/ml for both drugs. LOD and LOQ values were found to be 2.3 µg/ml and 3.45 µg/ml for Montelukast sodium and 2.67 µg/ml and

3.35 µg/ml for Fexofenadine hydrochloride respectively. The % RSD values were within the acceptable range. The developed method has been validated as per ICH guidelines.

Dimensions

Published

2013-01-07

Issue

Vol. 1 No. 1 (2013): 2013 Volume -1 - Issue 1

Section

Articles
Copyright & Licensing

Copyright (c) 2024 International Journal of Pharmaceuticals and Health Care Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.