Enhancement Of Solubility Dissolution Rate Of Atovaquone By Solid Dispersion Technique

Authors

  • B. Ananya Department Of Pharmaceutics, Svs Group Of Institutions (Autonomous) Bheemaram, Hanumakonda – 506015, Telangana. India.
  • Ch. Sudharani Department Of Pharmaceutics, Svs Group Of Institutions (Autonomous) Bheemaram, Hanumakonda – 506015, Telangana. India.
  • N Sravani Department Of Pharmaceutics, Svs Group Of Institutions (Autonomous) Bheemaram, Hanumakonda – 506015, Telangana. India.
  • E Laxman Department Of Pharmaceutics, Svs Group Of Institutions (Autonomous) Bheemaram, Hanumakonda – 506015, Telangana. India.
  • M Saikrishna Department Of Pharmaceutics, Svs Group Of Institutions (Autonomous) Bheemaram, Hanumakonda – 506015, Telangana. India.
  • K.Neelima Santhoshi Assistant Professor, Department of Pharmaceutics, SVS Group of Institutions (Autonomous), Bheemaram, Hanumakonda – 506015, Telangana. India.

Keywords:

Atovaquone, Solid dispersion, PVP- K30, Mannitol, PEG 20000, Urea and Polyplasdone XL.

Abstract

The present study was investigated that enhancement of dissolution rate of Atovaquone using solid dispersion method. For this study PVP- K30, Mannitol, PEG 20000 and Urea were used as carriers and Polyplasdone XL used as super disintegrate. Different ratios between drug and carriers were prepared. All formulations were evaluated for pre and post compression studies and those results were found to be within limits. Dissolution studies revealed that formulations F3 formulation was optimised formulation which contains Drug and Mannitol in the ratio of 1:1. FTIR studies revealed that no interactions between drug and excipients.

Published

2024-05-01