Recent Nanotechnology for Transdermal Drug Delivery System

Abstract

Transdermal drug delivery systems (TDDS) provide non-invasive alternative to standard administration methods, allowing for regulated drug release, increased patient compliance, and bypassing first-pass metabolism. Recent breakthroughs in nanotechnology have considerably increased the efficacy of transdermal medication delivery by bypassing the skin's barrier function, particularly the stratum corneum. This study focuses on the most recent discoveries in nanocarrier systems, such as liposomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, dendrimers, and microneedles, which are intended to improve drug penetration and therapeutic effects. We study a wide range of nano-enabled formulations, including ointments, patches, creams, and sprays, each customized to a unique therapeutic application, ranging from pain management and dermatological problems to chronic systemic diseases. The report also examines present obstacles and future directions in the sector, with the goal of providing a complete picture of how nanotechnology is transforming transdermal medication delivery.