Formulation and Evaluation of Curcuminoids and Flurbiprofen Granules Loaded Capsule and Its In-Vitro Anti-Rheumatic Activity

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by joint pain, stiffness, and progressive cartilage destruction. The present study aims to formulate and evaluate curcuminoids and flurbiprofen granules loaded capsules for their potential anti-rheumatic activity. Curcuminoids, derived from Curcuma longa, exhibit potent anti-inflammatory and antioxidant properties but suffer from poor bioavailability. Flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), effectively alleviates RA symptoms but is associated with gastrointestinal side effects. To overcome these limitations, this study explores the development of a combination formulation to improve therapeutic efficacy. The granules were prepared using the wet granulation method and encapsulated in hard gelatin capsules. The physicochemical properties of the formulations were assessed, including Fourier Transform Infrared Spectroscopy (FTIR) for compatibility studies, solubility analysis, and in-vitro dissolution studies to determine the drug release profile. The anti-rheumatic potential of the formulation was evaluated using in-vitro models, including free radical scavenging (DPPH assay) and albumin denaturation inhibition assays to assess anti-inflammatory properties. The optimized formulation F4 exhibited significant drug release and anti-rheumatic activity, suggesting its potential as a novel therapeutic approach for RA management.