FABRICATION AND CHARACTERIZATION OF BUCCOADHESIVE GELS OF LEVETIRACETAM FOR TRANSMUCOSAL DRUG DELIVERY AND ASSAY BY USING UPLC

Abstract

The purpose of the study is to fabricate and characterize buccoadhesive gels of levetiracetam for transmucosal drug delivery. Buccoadhesive dosage forms like buccoadhesive gels, tablets and films offer targeted site and controlled delivery of drugs through intrajugular vein. The dosage forms can be terminated from buccal cavity when ever required to avoid long exposure to drugs if therapeutic efficacy is attained, which is not possible with conventional dosage forms. Buccoadhesive dosage forms also bypasses the first pass metabolism. In this study different formulations of buccoadhesive gels containing levetiracetam were pepared and evaluated by performing invitro methods.