Preparation And Evaluation Of Microspheres Of Antidiabetic Drug By Solvent Evaporation Method

Abstract

 Microspheres, microscopic spherical particles, have garnered significant attention in recent years due to their potential applications in various fields, including pharmaceuticals, biotechnology, and medicine. This review aims to provide a comprehensive overview of the preparation and evaluation of microspheres. The study demonstrates the potential of microspheres as a controlled release delivery system for anti-diabetic therapy. The solvent evaporation method was found to be a suitable method for preparing microspheres with high entrapment efficiency and sustained release. The microspheres prepared in this study can be used for oral delivery, providing a convenient and patient-friendly treatment option for diabetes management. Various methods for preparing microspheres, such as solvent evaporation, spray drying, and emulsification, are discussed. The advantages and limitations of each method are highlighted, and the effects of formulation variables on microsphere characteristics are examined. The evaluation of microspheres, including their size, shape, surface morphology, and release kinetics, is also reviewed. Techniques such as scanning electron microscopy, transmission electron microscopy, and particle size analysis are discussed. Furthermore, the applications of microspheres in drug delivery, tissue engineering, and diagnostic imaging are explored. The challenges and future directions in microsphere research are also addressed.