Formulation Development And In Vitro Characterisation Of Deflazacort Extended Release Matrix Tablets

Abstract

The aim of the present study was to develop Extended release formulation of Deflazacort to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K100M, HPMC (K4M) and Carbopol 71G were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.85% in 12 hours. It contains the HPMC (K4M) as Extended release material. It followed peppas release kinetics mechanism