Solid Dispresion Strategies For Improved Amlodipine Besylate Performance: Preparation And Assessment

Abstract

Solid dispersion techniques have emerged as promising strategies for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs like amlodipine besylate. This review explores various solid dispersion approaches, including solvent evaporation, melting method, co- precipitation, spray drying, and supercritical fluid technology. These methods offer advantages such as increased drug solubility, improved dissolution kinetics, and enhanced oral bioavailability. Factors influencing the formulation and performance of solid dispersions, such ascarrier selection, drug-carrier interactions, and processing parameters, are discussed. Additionally, recent advancements in solid dispersion technology, such as nanostructured dispersions and inclusion complexation, are highlighted. Overall, solid dispersion techniques represent versatile and effective strategies for optimizing the therapeutic efficacy of amlodipine besylate formulations.