Formulation and Evaluation of Immediate-Release Tablets of Cenobamate

Abstract

The objective of this study was to formulate and evaluate immediate-release (IR) tablets of Cenobamate, an anticonvulsant drug, to enhance its bioavailability and therapeutic efficacy. Cenobamate, being poorly soluble in water, poses formulation challenges. Various excipients and approaches were employed to improve the drug's solubility and facilitate its rapid release. Immediate-release tablet formulations were prepared using direct compression, incorporating different concentrations of superdisintegrants Crospovidine (CP) , Croscarmellose sodium (CCS) and Sodium starch glycolate (SSG)) and fillers microcrystalline cellulose to optimize disintegration time, dissolution rate, and drug release profile. The tablets were characterized by physical parameters such as hardness, friability, weight variation, and content uniformity. In vitro dissolution studies were conducted to assess the release characteristics of cenobamate tablets, aiming for a rapid release in the first 30 minutes. The formulated tablets met pharmacopoeial standards for uniformity of weight, content, and dissolution, with a marked improvement in drug release compared to conventional tablet forms. The results indicated that the immediate-release cenobamate tablets have the potential to provide rapid onset of action, contributing to more efficient management of seizure disorders. This formulation offers an effective approach to enhance the bioavailability and clinical performance of cenobamate for better therapeutic outcomes.