Formulation and Evaluation of Amantadine Loaded Nanoparticles

Abstract

The present study was undertaken to formulate and evaluate amantadine-loaded nanoparticles with the objective of enhancing drug delivery and achieving sustained drug release. Amantadine-loaded nanoparticles were prepared using a suitable formulation technique and optimized to obtain desirable physicochemical characteristics. The prepared formulations were evaluated for precompression parameters including angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio. All the precompression parameters were found to be within Pharmacopoeial limits, indicating good flow properties and compressibility of the powder blend.

Post-compression evaluation of the formulated nanoparticles showed satisfactory results in terms of particle characteristics, drug content uniformity, and in vitro drug release studies. Among the different formulations, F3 was identified as the optimized formulation as it exhibited superior drug release, achieving 99.24% drug release over a period of 12 hours, demonstrating an effective sustained release profile. The results confirm that the optimized nanoparticle formulation possesses acceptable physicochemical properties and meets the required evaluation standards.

In conclusion, the successful formulation and evaluation of amantadine-loaded nanoparticles indicate that the developed nanoparticulate system is a promising approach for sustained drug delivery. The optimized F3 formulation, with its excellent release characteristics and parameters within Pharmacopoeial limits, may enhance therapeutic efficacy and improve patient compliance.