Formulation and Evaluation of Immediate Release Tablets of Imeglimin Hydrochloride

Abstract

Immediate release tablets are those tablets which disintegrate and release the drug Rapidly once it enters GIT. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance.  The aim is to formulate various formulations of immediate release tablet of Imeglimin Hydrochloride using different Super disintegrants (Sodium starch glycolate, PolyplasdoneXL10 and Ac- Di- Sol), Mannitol, Talc, Magnesium stearate and Lactose by direct compression method. The drug-excipients interaction was investigated by FTIR. The granules and tablets of Imeglimin Hydrochloride were evaluated for various pre and post compression parameters like angle of repose, compressibility index, hausners ratio, tablet hardness, friability and in vitro disintegration and dissolution studies and their results were found to be satisfactory. These results suggest that maximum in vitro dissolution profile of formulation F6 were found to have equivalent percentage of drug release and concluded that F6 is better and similar to innovator product.