Formulation Development And In Vitro Characterisation Of Deflazacort Extended Release Matrix Tablets

Authors

  • Amrytha Patil Department Of Pharmaceutics, Princeton College Of Pharmacy, Narapally, Ghatkesar, Telangana.
  • B.Thejovathi Department Of Pharmaceutics, Princeton College Of Pharmacy, Narapally, Ghatkesar, Telangana.
  • L.Harikiran Department Of Pharmaceutics, Princeton College Of Pharmacy, Narapally, Ghatkesar, Telangana.

Keywords:

Deflazacort, HPMC K100M, HPMC (K4M), Carbopol 71 G and Extended release system

Abstract

The aim of the present study was to develop Extended release formulation of Deflazacort to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K100M, HPMC (K4M) and Carbopol 71G were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.85% in  12 hours. It contains the HPMC (K4M) as Extended  release material. It followed peppas release kinetics mechanism.

Published

2024-05-01