Formulation And Evaluation Of Cytarabine Microspheres For Sustained Drug Delivery

Authors

  • Md.Adil Department of Pharmaceutics, Princeton College of Pharmacy In Narapally, Ghatkesar, Telangana
  • Zareena Shaik Department of Pharmaceutics, Princeton College of Pharmacy In Narapally, Ghatkesar, Telangana
  • L.Harikiran Department of Pharmaceutics, Princeton College of Pharmacy In Narapally, Ghatkesar, Telangana

Keywords:

Cytarabine, HPMC15cps Carbopol 934p, HPMC15000cps Carbopol 934p and solvent evaporation technique

Abstract

The Drug Cytarabine has short half life and hence requires frequent administration. Therefore the possible way for formulating a sustained release formulation of mucoadhesive microspheres. These formulations are prepared by solvent evaporation technique by using polymers HPMC15cps+Carbopol 934p and HPMC15000cps +Carbopol 934p. Various evaluation parameters assessed, with a view to obtain sustained release of Cytarabine. In the present study six formulations are formulated by using Sodium Alginate and HPMC15cps+Carbopol 934p and HPMC15000cps +Carbopol 934p various proportions. The prepared Cytarabine microspheres are then subjected to IR, SEM, particle size, % yield, Swelling Index, Micrometric, % Drug entrapment efficiency, In-vitro mucoadhesion test and in vitro dissolution studies. The IR Spectra revealed that, there is no interaction between the polymer and Cytarabine.  Cytarabine microspheres are spherical in nature, which was confirmed by SEM. The Optimized formulation C3 was found to release the drug for 12 h (99.13%) and follows peppas drug release kinetics model in dissolution studies.

Published

2024-05-01