Development And Charaterization Of Pravastatin Controlled Release Tablets To Treat Cardiovascular Disease

Abstract

Pravastatin is a statin medication, used preventing cardiovascular disease in those at high risk and treating abnormal lipids. It should be used together with diet changes, exercise, and weight loss. It is taken by mouth. In the present work, an attempt has been made to develop controlled release tablets of pravastatin by selecting natural polymers as retarding polymers. All the formulations were prepared by direct compression method using 6 mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per pharmacopeia limits. Among all the formulations F3 formulation showed maximum % drug release i.e., 98.91 % in 8 hours hence it is considered as optimized formulation. Whereas the formulations containing xanthan gum showed more retarding with increasing concentration of polymer. The formulations with Guar gum were unable to produce the desired rug release pattern.