Preparation And Evaluation Of Floating Tablets Of Clindamycin

Abstract

The purpose of this research was to formulate and evaluate the Floating sustained release tablets of Clindamycin 150mg, an antibiotic drug. Clindamycin is a medication used to treat bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media (middle ear infections), and endocarditis. The tablets are prepared by direct compression method. The formulations were optimized by incorporating varying composition of Eudragit RSPO, HPMC K 100, Chitosan and Micro crystalline cellulose as diluent, Sodium bicarbonate as floating agents, Magnesium stearate agent as lubricant. All the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The Preformulation parameters such as bulk density, tapped density, compressibility index and Hausner’s ratio were analyzed. The thickness, hardness, friability, weight variation, and drug content uniformity was evaluated for tablets. The effect of these variables on drug release also studied. The In-Vitro drug release studied were Performed in the USP dissolution apparatus-II (Paddle) using 0.1N HCL buffer as dissolution media at 50 rpm speed and temperature of 37oc ± 5^oC. the sampling was done at periodic time intervals of  0.5,1,2,3,4,5,6,7,8,9,10,11 and 12 hours and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV spectrophotometer. Based on the evaluation result the formulations F-3 containing Eudragit RSPO were selected as best formulation. The tablets were found to follow Kors mayer peppas release kinetics mechanism of drug release.