Formulation And Evaluation Of Floating Microspheres Of Bromohexine HCL By Using Different Polymers

Abstract

Objective: The primary objective of this study was to formulate and evaluate floating microspheres of bromhexine HCl to enhance its gastric retention time and achieve controlled drug release. The study aimed to explore the effects of different polymers on the microsphere characteristics and drug delivery profile.

Methods: Floating microspheres were prepared using various polymers, including Sodium Alginate, Guargum and Hydroxy propyl methyl cellulose through the solvent evaporation method. The formulations were characterized for their physicochemical properties, including particle size, drug entrapment efficiency, and floating behavior. In vitro drug release studies were conducted to assess the release kinetics and the ability of the microspheres to maintain floatation over time.

Results: The microspheres exhibited varying degrees of floating ability and controlled release characteristics depending on the polymer used. Among the different formulations, Guargum showed the optimal balance of prolonged floatation and sustained drug release. The drug entrapment efficiency was found to be 99.22%, and the microspheres demonstrated a zero-order, first-order release profile.

Conclusion: The study successfully developed floating microspheres of bromhexine HCl using different polymers, with Guargum showing the most promising results in terms of floating behavior and controlled drug release. These findings suggest that floating microsphere technology can significantly enhance the oral bioavailability and therapeutic efficacy of bromhexine HCl.