Formulation And Evaluation Of Oral Disintegrating Tablets Of Sertraline HCL

Abstract

A fast dissolving tablets was prepared by various ingredients like Croscarmellose, Sodium starch glycolate and Crospovidone with different ratios Chemical incompatibility studies confirmed that there is no interaction between drug and excipients used in the formulations. All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations SH6 emerged as the best formulation and showed maximum dissolution rate.